This site needs JavaScript to work properly. Shen ZJ, Wang Y, Ding GQ, Pan CW, Zheng RM. Thanhäuser A, Böhle A, Flad HD, Ernst M, Mattern T, Ulmer AJ. Mechanism of action of BCG Vaccine on Neoplastic Proliferation and Host Immune Responses, Bacillus Calmette‐Guerin vaccine—mechanism of action, effect on spleen weight, neoplastic proliferation, mice, Neoplastic proliferation—effect of BCG vaccine, mice, Spleen weight—effect of BCG vaccine, mice, BCG vaccine—mechanism of action, effect on spleen weight, neoplastic proliferation, mice. Pryor K, Stricker P, Russell P, Golovsky D, Penny R. Cancer Immunol Immunother. Clipboard, Search History, and several other advanced features are temporarily unavailable. Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. 1983 Apr;130(4):1492-4 The main use of BCG is for vaccination against tuberculosis. Patard JJ, Saint F, Velotti F, Abbou CC, Chopin DK. Presented at the Annual Meeting of the Federation of the American Societies for Experimental Biology, Atlantic City, N.J., April 13-18,1975. and you may need to create a new Wiley Online Library account. -. Cancer Immunol Immunother. The spleen lymphocytes from the BCG‐treated sarcoma‐bearing animals had no effect against 51Cr‐ or 14C‐2‐thymidine‐labeled sarcoma cells. The impacts of these … BCG (Bacillus Calmette‐Guerin) vaccine, Tice strain, caused a threefold increase in spleen weight of normal animals and a fourfold increase in spleen weight of sarcoma‐bearing mice. These mechanisms are also involved in tumor rejection, and the identification of some specific tumor rejection antigens presented to specific CTLs could provide new therapeutic approaches. World J Urol. The most likely mechanism of action of BCG immunotherapy involves a combination of its direct effect on tumor cells along with the patient’s immune response to the therapy. There are some experimental and clinical data suggesting that BCG antigens are processed not only by immunocompetent cells but also by urothelial cells and tumor cells. Please enable it to take advantage of the complete set of features! Author information: (1)Department of Urology, Medical University of Lübeck, Germany. NCI CPTC Antibody Characterization Program, J Urol. We use cookies to help provide and enhance our service and tailor content and ads. Despite being the most widely used vaccine in human history, the mechanisms of attenuation of BCG remain poorly understood. There are some experimental and clinical data suggesting that BCG antigens are processed not only by immunocompetent cells but also by urothelial cells and tumor cells. Br J Cancer. The serum of BCG‐treated sarcoma‐bearing animals inhibited the spleen lymphocyte‐mediated cytotoxic action. 1984 Sep;132(3):570-3. doi: 10.1016/s0022-5347(17)49748-5. Immune response following intravesical bacillus Calmette-Guerin instillations in superficial bladder cancer: a review. This discussion suggests that the effects of BCG on the immune system, although many and varied, may act on tumor cells from 2 main directions, from either (1) the actions on the immune system that, from other studies, seem to require live BCG organisms or (2) the direct actions on tumor cells that may be activated with dead BCG. Bacillus Calmette-Guerin (BCG) is an immunostimulant that is used to stimulate the immune system to produce immunity against tuberculosis. -, Urol Res.
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